Semax dosage calculator
Enter a vial and a dose and this returns the concentration, the volume and the syringe units. Underneath it, the same arithmetic worked out in advance for common vials, and the doses published studies of Semax actually used, every one quoted and cited. It converts numbers. It does not suggest what to take.
Work out concentration and what to draw
Two divisions, both shown. Concentration = mass in the vial ÷ diluent volume. Volume to draw = mass you want ÷ that concentration. Syringe units are that volume × the units per millilitre on your syringe's own scale.
Worked example: 5 mg in 2 mL is 2,500 mcg/mL, so 250 mcg is 0.1 mL, which is 10 units on a U-100 syringe and 4 units on a U-40. The scale is printed on the barrel; reading a U-40 syringe as if it were U-100 is a two-and-a-half-fold error.
Semax reconstitution chart
Units on a standard U-100 insulin syringe, where 100 units is 1 mL. The rows are the absolute doses quoted in studies of Semax, from 6 mg to 6 mg, so this chart is specific to this compound rather than a generic ladder. More diluent means more units for the same dose, which is easier to measure accurately and empties the vial no faster.
| Dose | 1 mL diluent (2,000 mcg/mL) | 2 mL diluent (1,000 mcg/mL) | 3 mL diluent (667 mcg/mL) |
|---|---|---|---|
| 6 mg | 300 >1 mL | 600 >1 mL | 900 >1 mL |
| Dose | 1 mL diluent (5,000 mcg/mL) | 2 mL diluent (2,500 mcg/mL) | 3 mL diluent (1,667 mcg/mL) |
|---|---|---|---|
| 6 mg | 120 >1 mL | 240 >1 mL | 360 >1 mL |
| Dose | 1 mL diluent (10,000 mcg/mL) | 2 mL diluent (5,000 mcg/mL) | 3 mL diluent (3,333 mcg/mL) |
|---|---|---|---|
| 6 mg | 60 | 120 >1 mL | 180 >1 mL |
Read a figure off this chart only if it matches the vial in front of you. A vial labelled a different strength, or reconstituted with a different volume, gives a different number for the same dose, and that is the single most common way these calculations go wrong.
Doses in published studies of Semax
Each row is quoted from a paper in this compound's source ledger and carries the kind of evidence it came from. 2 of 4 come from human studies; the rest are animal or laboratory work.
| Evidence | Dose as the paper states it | Source |
|---|---|---|
| Human clinical trial | Clinical trial, humans, n=43, 2018: doses stated in the abstract: 6000 mcg/day. Standard regimen of semax included 2 courses (6000 mcg/day) for 10 days with 20 day interval. | pmid-29798983 |
| Observational, human | Human study, humans, n=58, 2015: doses stated in the abstract: 600 mg/day. In group 1, 58 patients received conventional therapy, while 60 patients in group 2 received the same with additional 0.1% semax solution intranasally 600 mg/day for 10 days. | pmid-27051926 |
| Animal, preclinical | Animal study, rats, 2021: doses stated in the abstract: 25 μg/kg. Mexidol (100 mg/kg) was administered intraperitoneally, and Semax (25 μg/kg) was administered intranasally, for 7 days each. | pmid-33806692 |
| Animal, preclinical | Animal study, rats, 2020: doses stated in the abstract: 200 μg/kg. Deltalicin in a dose 100 μg/kg and Semax in a dose 200 μg/kg as well as sulodexide corrected lipid metabolism disorders: the content of total cholesterol, triglycerides, LDL, index of atherogenicity decreased and HDL concentration increased. | pmid-32246363 |
Weight-normalised doses, and why they are not on the chart
Some studies state a dose per kilogram. Those figures are deliberately absent from the chart above, because multiplying one by a body weight produces a number that looks like a dose and is not one. Interspecies scaling is not arithmetic: a rat milligram-per-kilogram figure does not become a human dose by multiplication.
- Animal study, rats, 2021: weight-normalized doses as published: 25 μg/kg. Mexidol (100 mg/kg) was administered intraperitoneally, and Semax (25 μg/kg) was administered intranasally, for 7 days each. pmid-33806692
- Animal study, rats, 2020: weight-normalized doses as published: 200 μg/kg. Deltalicin in a dose 100 μg/kg and Semax in a dose 200 μg/kg as well as sulodexide corrected lipid metabolism disorders: the content of total cholesterol, triglycerides, LDL, index of atherogenicity decreased and HDL concentration increased. pmid-32246363
How long studies ran, and how far a vial goes
A vial lasts for a number of draws, not a number of weeks: divide the mass in the vial by the mass per draw and round down, which the vial planner does. How long that represents depends on frequency. For context, these are the durations studies of Semax actually ran for.
- Randomized controlled trial, humans, n=27, 2007: durations stated: 10 day; 2 weeks. The drug was administered intranasally in two 10-day-long courses with 2-weeks break in daily dose of 12 mg. pmid-18379501
- Controlled clinical trial, humans, n=30, 1997: durations stated: 10 days. The most effective daily doses were 12 mg for patients with strokes of moderate severity and 18 mg for patients with severe strokes (treatment course--5 and 10 days). pmid-11517472
- Human study, humans, n=58, 2015: durations stated: 10 days. In group 1, 58 patients received conventional therapy, while 60 patients in group 2 received the same with additional 0.1% semax solution intranasally 600 mg/day for 10 days. pmid-27051926
- Animal study, rats, 2021: durations stated: 7 days; 21 days. Mexidol (100 mg/kg) was administered intraperitoneally, and Semax (25 μg/kg) was administered intranasally, for 7 days each. pmid-33806692
- Animal study, rats, 2021: durations stated: 40 weeks. Rat pups received FA or vehicle injections on postnatal days 1-14, a time period equivalent to 27-40 weeks of human foetal age. pmid-33418449
Storage and stability, as published
Reconstitution starts a clock. These are the storage and stability conditions stated in papers in this ledger. They describe what the study did, which is not the same as a shelf life for a vial in your fridge.
- Human study, humans, 2005: Semax treatment resulted in significant clinical improvement, stabilization of the disease progress and reduced a risk of stroke and transitory ischemic attacks in the disease course. pmid-15792140
- Animal study, rats, 2008: The stability of Semax in cell cultures was tested by HPLC analysis. pmid-18431004
- Animal study, mice, n=2, 2004: Semax is a peptide analogue of ACHT4-10 fragment which is resistant to degradation. pmid-15658043
How Semax was given
The route changes what a dose means. The same number given intravenously and subcutaneously is not the same exposure.
- Human study, humans, n=58, 2015: administration by intranasal route reported. In group 1, 58 patients received conventional therapy, while 60 patients in group 2 received the same with additional 0.1% semax solution intranasally 600 mg/day for 10 days. pmid-27051926
- Animal study, rats, 2024: administration by intraperitoneal route reported. Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII. pmid-39442746
- Animal study, rats, 2024: administration by intraperitoneal route reported. Here, we used high-throughput RNA sequencing (RNA-Seq) to identify differentially expressed genes (DEGs) in the brain frontal cortex of rat receiving intraperitoneal administration of ACTH-like peptides ACTH(4-7)PGP (Semax) and ACTH(6-9)PGP, or saline. pmid-39418522
- Animal study, rats, 2021: administration by intranasal, intraperitoneal route reported. Mexidol (100 mg/kg) was administered intraperitoneally, and Semax (25 μg/kg) was administered intranasally, for 7 days each. pmid-33806692
- Animal study, rats, 2021: administration by intraperitoneal route reported. We studied the effect of intraperitoneal administration ACTH (4-7) -PGP in doses of 5, 50, 150, and 450 μg/kg to Wistar male rats 12-15 min before modeling restraint stress on the morphofunctional state of the colon. pmid-33459919
- Animal study, mice, n=2, 2004: administration by subcutaneous route reported. DBA/2, CBA mice, and their F1 hybrids (first series) and 101/HY and C3H mice (second series) were injected as neonates (2-7 days of life) with Semax (sc., 7 microg per animal). pmid-15658043
Questions people ask
- How many units is 6 mg of Semax?
- It depends entirely on how the vial was reconstituted. In a 5 mg vial with 2 mL of diluent it is 240 units on a U-100 syringe; with 1 mL it is 120. The chart above gives the rest.
- Does adding more diluent waste the peptide?
- No. The mass in the vial does not change. More diluent spreads the same mass through more liquid, so each dose is a larger, easier-to-measure volume and the vial yields exactly as many doses as before.
- Why does this page not recommend a dose?
- Because a dose is a clinical decision rather than a division. It depends on why someone is taking something, what else they take and how their kidneys and liver are working, none of which is knowable from a number typed into a box.
- Where do the doses in the table come from?
- Each is quoted from a specific paper indexed in Europe PMC, linked in the source column, and labelled with the kind of study it came from. The full evidence is on the Semax record.
What this calculator will not do
It will not take a body weight and return a milligram figure, and it will not tell you how often to draw. The table above is the published record, not a menu. A dose that appeared in a trial appeared under supervision, with monitoring, in people selected for that trial.
Other calculators
- Generic reconstitution calculatorThe same arithmetic, without a compound attached
- Unit convertermg, mcg, ng and syringe units
- Vial plannerDraws per vial and how long it lasts
- All compound calculatorsEvery compound with published dose figures