Humanin dosage calculator
Enter a vial and a dose and this returns the concentration, the volume and the syringe units. Underneath it, the same arithmetic worked out in advance for common vials, and the doses published studies of Humanin actually used, every one quoted and cited. It converts numbers. It does not suggest what to take.
Work out concentration and what to draw
Two divisions, both shown. Concentration = mass in the vial ÷ diluent volume. Volume to draw = mass you want ÷ that concentration. Syringe units are that volume × the units per millilitre on your syringe's own scale.
Worked example: 5 mg in 2 mL is 2,500 mcg/mL, so 250 mcg is 0.1 mL, which is 10 units on a U-100 syringe and 4 units on a U-40. The scale is printed on the barrel; reading a U-40 syringe as if it were U-100 is a two-and-a-half-fold error.
Why there is no units chart for Humanin
Every dose quoted in studies of Humanin is given per kilogram of body weight, and none is an absolute quantity. A chart of syringe units needs a fixed mass to work from, so there is nothing honest to put in one.
The obvious move — multiply a per-kilogram figure by a body weight — is the one thing that must not be done here. Most of these figures come from rats or mice, and dose does not scale between species by arithmetic: surface area, metabolic rate and clearance all differ, which is why interspecies conversion is a calculation with published factors and assumptions rather than a multiplication. A number produced that way would look like a dose and carry none of the evidence a dose needs.
The calculator above still works. Give it the vial and the mass you intend to draw and it returns the volume and the units. What it cannot do, for this compound, is tell you what that mass should be, because no study in this ledger states one.
Doses in published studies of Humanin
Each row is quoted from a paper in this compound's source ledger and carries the kind of evidence it came from. None is a human dose: no study here administered Humanin to people at a stated dose.
| Evidence | Dose as the paper states it | Source |
|---|---|---|
| Animal, preclinical | Rats received humanin at 1 mg/kg a day by subcutaneous infusion alongside paroxetine. | pmid-42480246 |
| Animal, preclinical | Diabetic mice received humanin 4 mg/kg intraperitoneally for 15 days. | pmid-42438323 |
| Animal, preclinical | Rats with retinal degeneration received the analogue HNG at 0.4 or 4 mg/kg intraperitoneally twice a week for one or four weeks. | pmid-42471450 |
| Mechanistic, in vitro | Human muscle cells in culture were treated with 10 micromolar HNG or MOTS-c against dexamethasone. | pmid-41732124 |
Weight-normalised doses, and why they are not on the chart
Some studies state a dose per kilogram. Those figures are deliberately absent from the chart above, because multiplying one by a body weight produces a number that looks like a dose and is not one. Interspecies scaling is not arithmetic: a rat milligram-per-kilogram figure does not become a human dose by multiplication.
- 4 mg/kg intraperitoneal in mice and rats; 0.4 mg/kg as the low dose in rats; 1 mg/kg/day by subcutaneous infusion in rats. pmid-42438323
How long studies ran, and how far a vial goes
A vial lasts for a number of draws, not a number of weeks: divide the mass in the vial by the mass per draw and round down, which the vial planner does. How long that represents depends on frequency. For context, these are the durations studies of Humanin actually ran for.
- Fifteen days of daily injection in diabetic mice; one or four weeks of twice-weekly HNG in rats. pmid-42438323
How Humanin was given
The route changes what a dose means. The same number given intravenously and subcutaneously is not the same exposure.
- Animal study, rats, n=10, 2026: administration by oral, subcutaneous route reported. In Phase 1, fifty rats were randomized into control, sham, paroxetine (20 mg/kg/day via oral gavage), humanin (1 mg/kg/day via subcutaneous infusion), and paroxetine + humanin groups (n = 10/group) to evaluate sexual behavior, sperm quality, serum… pmid-42480246
- Animal study, mice, n=10, 2026: administration by intraperitoneal route reported. Humanin (4 mg/kg) was administered intraperitoneally for 15 days following diabetes induction. pmid-42438323
- Animal study, mice, n=10, 2026: administration by intraperitoneal route reported. Humanin was administered intraperitoneally for 15 consecutive days. pmid-42346352
Questions people ask
- Does adding more diluent waste the peptide?
- No. The mass in the vial does not change. More diluent spreads the same mass through more liquid, so each dose is a larger, easier-to-measure volume and the vial yields exactly as many doses as before.
- Why does this page not recommend a dose?
- Because a dose is a clinical decision rather than a division. It depends on why someone is taking something, what else they take and how their kidneys and liver are working, none of which is knowable from a number typed into a box.
- Where do the doses in the table come from?
- Each is quoted from a specific paper indexed in Europe PMC, linked in the source column, and labelled with the kind of study it came from. The full evidence is on the Humanin record.
What this calculator will not do
It will not take a body weight and return a milligram figure, and it will not tell you how often to draw. The table above is the published record, not a menu. For Humanin there is no human dose in this ledger to copy even if you wanted one.
Other calculators
- Generic reconstitution calculatorThe same arithmetic, without a compound attached
- Unit convertermg, mcg, ng and syringe units
- Vial plannerDraws per vial and how long it lasts
- All compound calculatorsEvery compound with published dose figures