:root{--ink: #17202a;--ink-2: #4a5663;--ink-3: #6f7c89;--paper: #fbfbf9;--surface: #ffffff;--rule: #dde2e7;--sunk: #f1f3f5;--accent: #1f5fa8;--t-approved: #12704a;--t-trial: #1f5fa8;--t-obs: #5b6ea8;--t-animal: #b4700f;--t-vitro: #8a5a2b;--t-community: #a8324a;--t-editorial: #5d6b7a;--serif: Georgia, "Times New Roman", serif;--sans: system-ui, -apple-system, "Segoe UI", Roboto, sans-serif;--mono: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace}@media(prefers-color-scheme:dark){:root{--ink:#e4e9ee;--ink-2:#a7b1bb;--ink-3:#7f8a95;--paper:#0e1317;--surface:#151c22;--rule:#28323b;--sunk:#111820;--accent:#5a9be0;--t-approved:#2fb07e;--t-trial:#5a9be0;--t-obs:#8fa0d6;--t-animal:#d49a3a;--t-vitro:#c48a5a;--t-community:#e07a90;--t-editorial:#98a6b5}}*{box-sizing:border-box}html{color-scheme:light dark}body{margin:0;background:var(--paper);color:var(--ink);font:16px/1.6 var(--sans)}a{color:var(--accent)}code{font-family:var(--mono);font-size:.9em;background:var(--sunk);padding:.05em .3em;border-radius:3px}.wrap{max-width:72rem;margin:0 auto;padding:0 1.25rem}.prose{max-width:68ch}h1,h2,h3{font-family:var(--serif);line-height:1.2;margin:0;letter-spacing:-.01em;text-wrap:balance}h1{font-size:clamp(1.8rem,3.5vw,2.6rem)}h2{font-size:1.45rem;margin-top:2.5rem;padding-bottom:.4rem;border-bottom:1px solid var(--rule)}h3{font-size:1.1rem;margin-top:1.25rem}p{margin:.6rem 0}.site-head{border-bottom:1px solid var(--rule);background:var(--surface)}.site-head .wrap{display:flex;flex-wrap:wrap;gap:1rem 2rem;align-items:baseline;padding:1rem 1.25rem}.site-head .brand{font-family:var(--serif);font-weight:600;color:var(--ink);text-decoration:none}.site-head nav a{margin-right:1.1rem;color:var(--ink-2);text-decoration:none;font-size:.95rem}.site-foot{margin-top:4rem;border-top:1px solid var(--rule);padding:2.25rem 0 2.5rem;color:var(--ink-3);font-size:.9rem;background:var(--surface)}.foot-grid{display:grid;grid-template-columns:minmax(0,2fr) minmax(0,1fr) minmax(0,1fr);gap:2rem 3rem}.foot-col{display:flex;flex-direction:column;gap:.4rem}.foot-col a{color:var(--ink-2);text-decoration:none}.foot-col a:hover{color:var(--ink);text-decoration:underline}.foot-brand{font-family:var(--serif);font-weight:600;color:var(--ink);font-size:1.05rem;margin:0 0 .5rem}.foot-about p{margin:0;max-width:52ch;line-height:1.55}.foot-head{font-family:var(--mono);font-size:.7rem;letter-spacing:.12em;text-transform:uppercase;color:var(--ink-3);margin:0 0 .35rem}.foot-meta{display:flex;flex-wrap:wrap;justify-content:space-between;gap:.5rem 2rem;margin-top:2rem;padding-top:1.25rem;border-top:1px solid var(--rule);font-size:.8rem}@media(max-width:720px){.foot-grid{grid-template-columns:1fr 1fr}.foot-about{grid-column:1 / -1}}.eyebrow{font-family:var(--mono);font-size:.72rem;letter-spacing:.12em;text-transform:uppercase;color:var(--ink-3)}.lede{color:var(--ink-2);font-size:1.05rem}.notice{border:1px solid var(--rule);border-left:3px solid var(--t-animal);background:var(--surface);padding:.8rem 1rem;border-radius:0 4px 4px 0;margin:1.25rem 0}.notice.good{border-left-color:var(--t-approved)}.label{display:inline-block;font-family:var(--mono);font-size:.7rem;letter-spacing:.06em;text-transform:uppercase;padding:.15em .5em;border-radius:3px;color:#fff;vertical-align:middle}.label[data-tier=approved-label]{background:var(--t-approved)}.label[data-tier=human-clinical-trial]{background:var(--t-trial)}.label[data-tier=observational-human]{background:var(--t-obs)}.label[data-tier=animal-preclinical]{background:var(--t-animal)}.label[data-tier=mechanistic-in-vitro]{background:var(--t-vitro)}.label[data-tier=community-reported]{background:var(--t-community)}.label[data-tier=editorial]{background:var(--t-editorial)}dl.facts{display:grid;grid-template-columns:max-content 1fr;gap:.4rem 1.25rem;margin:1rem 0}dl.facts dt{color:var(--ink-3);font-size:.9rem}dl.facts dd{margin:0}table{border-collapse:collapse;width:100%;font-size:.95rem}th,td{text-align:left;padding:.55rem .7rem;border-bottom:1px solid var(--rule);vertical-align:top}th{font-family:var(--mono);font-size:.72rem;letter-spacing:.08em;text-transform:uppercase;color:var(--ink-3);font-weight:500}td.num,th.num{text-align:right;font-variant-numeric:tabular-nums}.tscroll{overflow-x:auto}ul.claims{list-style:none;padding:0;margin:.5rem 0}ul.claims li{padding:.6rem 0;border-bottom:1px solid var(--rule)}ul.claims .cite{font-family:var(--mono);font-size:.8rem;color:var(--ink-3);margin-left:.4rem}ol.sources li{margin:.5rem 0;font-size:.95rem}ol.sources .meta{color:var(--ink-3);font-size:.85rem}.cards{display:grid;grid-template-columns:repeat(auto-fill,minmax(16rem,1fr));gap:.75rem;list-style:none;padding:0;margin:1rem 0}.cards li{background:var(--surface);border:1px solid var(--rule);border-radius:5px;padding:.85rem 1rem}.cards a{text-decoration:none;color:var(--ink);font-weight:600}.cards .sub{color:var(--ink-3);font-size:.85rem;margin-top:.25rem}.calc{background:var(--surface);border:1px solid var(--rule);border-radius:5px;padding:1rem 1.25rem;margin:1rem 0}.calc label{display:block;margin:.6rem 0 .2rem;font-size:.9rem;color:var(--ink-2)}.calc input{font:inherit;padding:.4rem .6rem;border:1px solid var(--rule);border-radius:4px;width:100%;max-width:18rem;background:var(--paper);color:var(--ink)}.calc output{display:block;margin-top:.9rem;font-family:var(--mono)}.claim-value{margin:0}details.excerpt{margin:.35rem 0 0;font-size:.92rem}details.excerpt summary{color:var(--ink-3);cursor:pointer;font-size:.82rem}details.excerpt blockquote{margin:.4rem 0 0;padding:.5rem .9rem;border-left:3px solid var(--rule);color:var(--ink-2);background:var(--sunk);border-radius:0 4px 4px 0}table.evidence{font-size:.88rem}table.evidence td.outcome{min-width:18rem;color:var(--ink-2)}.refcard{background:var(--surface);border:1px solid var(--rule);border-radius:5px;padding:1rem 1.25rem;margin:1rem 0}.refcard-head{display:flex;justify-content:space-between;gap:1rem}.refcard-foot{color:var(--ink-3);font-size:.85rem;margin-top:.5rem}@media print{.site-head,.site-foot,details.excerpt{display:none}}.claim-lead{color:var(--ink-2)}q.claim-quote{quotes:"“" "”";color:var(--ink)}